Adrenal cortex and medulla hormones4/5/2023 ![]() Norepinephrine has less effect on cardiac output.ĥ. It causes vasodilatation of the arterioles of the skin and mucous membranes. It increases the irritability and the rate and strength of contraction of cardiac muscle and increases cardiac output. Epinephrine is an effective stimulant of heart action. Epinephrine acts on adipose tissue and releases free fatty acids into the circulation.Ĩ. Epinephrine causes increased breakdown of muscle glycogen to lactic acid, thereby increasing blood lactate.Ħ. ![]() ![]() Norepinephrine is one-fifth potent in this respect.ĥ. cAMP stimulates phosphorylase which causes the breakdown of glycogen in the liver resulting in increased blood sugar. Epinephrine increases cAMP by activating adenylate cyclase. They are destroyed by oxidation when given orally.Ĥ. These hormones are effective on parenteral administration. In this sense, it mobilizes the terms “fight or flight” mechanism.Ģ. Epinephrine gives a rapid physiologic response to emergencies such as cold, fatigue, shock etc.
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